Pharmacology

Programmed cell death, also known as apoptosis, is crucial for maintaining cellular homeostasis and plays a significant role in tumor development, progression, and resistance to treatment. Evading apoptosis has been a characteristic of cancer, and apoptotic signaling pathways have been proposed as targets of anticancer drug development. Emodin, a naturally occurring anthraquinone produced by medicinal plants, has become a promising...

Background: Oxaliplatin is a widely used platinum-based chemotherapeutic agent, and its cardiotoxicity remains an important safety concern during cancer treatment. Astragalus -derived saponins have been reported to exert cardioprotective effects; however, the specific active constituent responsible for protecting against oxaliplatin-induced myocardial injury has not been identified. Methods: Several Astragalus saponins and related...

Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic cystic tumor with variable malignant potential. Surgical resection remains the standard treatment for high-risk cases, whereas low-risk patients are typically managed with surveillance. This study presents two clinical cases treated with a rhubarb-centered therapeutic strategy. Both patients demonstrated symptomatic improvement and stable imaging findings....

Background: Hyperuricemia is a common metabolic disease, which seriously affects the quality of life of patients. Salidroside (SAL) is a natural phenolic product extracted from Rhodiola rosea root, which is not only less toxic, but also beneficial for metabolic diseases. Purpose: To investigate SAL's role in regulating hyperuricemia and explore the potential mechanism. Methods: Molecular simulation was employed to predict the...

Background: Potential acute and chronic oral toxic effects of Dendrobium officinale (DO) and black tea extract (BTE) mixture, a health-care food for osteoporosis, were evaluated to assess its suitability for therapeutic exploitation. Materials & Methods: Acute toxicity was examined via intragastric administration of DO-BTE twice within 24 h at 5 g/kg for a 14-day observation. In the subchronic toxicity test, normal rats were orally...